Tumor necrosis factor-alpha in diastolic heart failure
نویسندگان
چکیده
منابع مشابه
Evaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis
Background The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are important factors in reproductive-related disorders. One of the most common gynecological diseases of women during the reproductive years is endo...
متن کاملIncreased expression of tumor necrosis factor-alpha converting enzyme and tumor necrosis factor-alpha in peripheral blood mononuclear cells in patients with advanced congestive heart failure.
BACKGROUND Tumor necrosis factor-alpha converting enzyme (TACE) has recently been identified as a metalloproteinase-disintegrin, which converts pro-tumor necrosis factor-alpha (TNF-alpha) to the mature form, and is an important mediator in the pathogenesis of CHF. AIMS In order to establish the importance of TACE in the regulation of TNF-alpha synthesis in peripheral blood mononuclear cells (...
متن کامل[Tumor necrosis factor-alpha in heart failure: more questions than answers].
24 Heart failure (HF) as a clinical syndrome is posing an increasing social and economic burden, particularly in developed countries with their ageing populations.1 No single pathophysiological mechanism can explain the clinical manifestations of HF, which presents as the unfavourable endpoint of a many cardiac diseases; most commonly ischaemic heart disease, hypertension, idiopathic dilated ca...
متن کامل[Importance of tumor necrosis factor-alpha in the pathogenesis of heart failure].
Clinical and experimental evidence demonstrating the effects of tumor necrosis factor-alpha (TNF-alpha) in patients with heart failure continues to accumulate. It is well established that high concentrations of TNF-alpha appear in the circulation of patients with heart failure and that these levels have a directly proportional correlation with the patient's functional class. TNF-alpha levels al...
متن کاملTumor necrosis factor-alpha as trigger of platelet activation in patients with heart failure.
The clinical history of patients with heart failure (HF) is complicated by arterial thromboembolism. Platelet activation is reported in this population, but the underlying mechanism has not been clarified. Forty-two patients with HF scored according to New York Heart Association (NYHA) classification had higher levels of collagen-induced platelet aggregation, platelet tumor necrosis factor-alph...
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ژورنال
عنوان ژورنال: European Journal of Heart Failure
سال: 2000
ISSN: 1388-9842
DOI: 10.1016/s1388-9842(00)80028-8